Hodzic, J., Sie, D., Vermeulen, A., Van Beusechem, V.W. (2017)
Functional screening identifies human miRNAs that modulate adenovirus propagation in prostate cancer cells.
Hum. Gene Ther., January 2017, ahead of print. doi: 10.1089/hum.2016.143.
Online Ahead of Editing: January 23, 2017.
Dong, W., Van Ginkel, J.W.H., Au, K.Y., Alemany, R., Meulenberg, J.J.M., Van Beusechem, V.W. (2014)
ORCA-010, a novel potency-enhanced oncolytic adenovirus, exerts strong antitumor activity in preclinical models.
Hum. Gene Ther., 25:897–90.
Gros, A., Martínez-Quintanilla J., Puig, C., Guedan, S., Molleví, D.G., Alemany, R., Cascallo, M. (2008)
Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency.
Cancer Res. 68: 8928-8937.
Schagen, F.H.E., Graat, H.C.A., Carette, J.E., Vellinga, J., Van Geer, M.A., Hoeben, R.C., Dermody, T.S. and Van Beusechem, V.W. (2008)
Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishe s hepatic tropism and enhances bioavailability in mice.
Hum. Gene Ther., 19:783-794.
Idema, S., Lamfers, M.L.M., Van Beusechem, V.W., Heukelom, S., Moeniralm, S., Gerritsen, W.R., Vandertop, P.W., Dirven, C.M.F. (2007)
Combined radiation and viral therapy with the p53-expressing oncolytic adenovirus AdΔ24-p53 achieves potent anti-tumor activity in malignant glioma.
J. Gene Med., 9:1046-1056.
Graat, H.C.A., Carette, J.E., Schagen, F.H.E., Vassilev, L.T., Gerritsen, W.R., Kaspers, G.J.L., Wuisman, P.I.J.M., Van Beusechem, V.W. (2007)
Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of MDM2 and adenoviruses encoding p53.
Mol. Cancer Ther., 6:1552-1561.
Schagen, F.H.E., Wensveen, F.M., Carette, J.E., Dermody, T.S., Gerritsen, W.R., Van Beusechem, V.W. (2006)
Genetic targeting of adenovirus vectors using a reovirus σ1-based attachment protein.
Mol. Ther., 13:997-1005.
Van Beusechem, V.W., Van den Doel, P.B., Gerritsen, W.R. (2005)
Conditionaly replicative adenovirus expressing degradation-resistant p53 for enhanced oncolysis of human cancer cells overexpressing MDM2.
Mol. Cancer Ther., 4:1013-1018.
Geoerger, B., Van Beusechem, V.W., Opolon, P., Morizet, J., Laudani, L., Lecluse, Y., Barrois, M., Idema, S., Grill, J., Gerritsen, W.R., Vassal, G. (2005)
Expression of p53, or targeting towards EGFR enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma.
J. Gene Med., 7:584-594.
Heideman, D.A.M., Steenbergen, R.D.M., Van der Torre, J., Scheffner, M., Alemany, R., Gerritsen, W.R., Meijer, C.J.L.M., Snijders, P.J.F., Van Beusechem, V.W. (2005)
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancers.
Mol. Ther., 12:1083-1090.
Carette, J.E., Graat, H.C.A., Schagen, F.H.E., Abou El Hassan, M.A.I., Gerritsen, W.R., Van Beusechem, V.W. (2005)
Replication-dependent transgene expression from a conditionally replicating adenovirus via alternative splicing to a heterologous splice acceptor site.
J. Gene Med., 7:1053-1062.
Carette, J.E., Overmeer, R.M., Schagen, F.H.E., Alemany, R., Barski, O., Gerritsen, W.R., Van Beusechem, V.W. (2004)
Conditionally replicating adenoviruses expressing short hairpin RNAs silence the expression of a target gene in cancer cells.
Cancer Res., 64:2663-2667.
Geoerger, B., Vassal, G., Opolon, P., Dirven, C.M.F., Morizet, J., Laudani, L., Grill, J., Giaccone, G., Vandertop, P.W., Gerritsen, W.R., Van Beusechem, V.W. (2004)
Oncolytic activity of p53-expressing conditionally replicative adenovirus AdΔ24-p53 against human malignant glioma.
Cancer Res., 64:5753-5759.
Van Beusechem, V.W., Van den Doel, P.B., Grill, J., Pinedo, H.M., and Gerritsen, W.R. (2002)
Conditionaly replicative adenovirus expressing p53 exhibits enhanced oncolytic potency.
Cancer Res., 62: 6165-6171.